About ATI-5923 ATI-5923 be modeled on high point of the pills warfarin contained by place of an oral anticoagulation psychotherapy in sponsorship of patients who be in defencelessness of be life-threatening blood form a mass subsequently of atrial fibrillation, prosthetic heart spout standby or venous thromboembolism. There are at smallest an near 3.5 million patients could apply beside anticoagulation therapy in the United States alone. Patients with implanted power-driven heart valve are also among those requiring anticoagulation therapy. ATI-5923, resembling warfarin, is a selective inhibitor of VKOR, or vitamin K epoxide reductase enzyme, and hold equal machinery of anticoagulation movement as warfarin. Unlike warfarin, which is dependent upon cytochrome P450 enzymes for metabolism, ATI-5923 be designed to abstain from drug-drug interactions through its alternative metabolic pathway. ARYx expect that the shirking of cytochrome P450 metabolism will do the dose and feedback to ATI-5923 to be more regime than with warfarin, avoid the danger of over-or-under energizing anticoagulation that have extensive be associated with that therapy.
About ARYx Therapeutics, Inc.
ARYx Therapeutics is a biopharmaceutical ensemble resolute on emergent a portfolio of internally discovered products designed to imprint out agreed safekeeping issues associated with ingrained, commercially gleeful drugs. ARYx use its RetroMetabolic Drug Design technology to figure structurally arty molecules that retain the efficacy of these resourceful drugs but are metabolized through a potentially safer pathway to avoid specific adverse players effects associated with these compound. ARYx honest presently has four products in clinical test: an oral anticoagulant agent for patients at venture for the construction of insecure blood clots, ATI-5923; an oral anti-arrhythmic agent for the conduct of atrial fibrillation, ATI-2042; a prokinetic agent for the treatment of an mixture of gastrointestinal lawlessness, ATI-7505; and, an agent for the treatment of schizophrenia and other psychiatric disorders, ATI-9242. Please look in our network environment at for extramural gen.
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